Lukas Fassler from Soldernerd shares his experience with DirtyPCBs:
I can think of a lot of situations where it could be useful. But the main reason for this project was to gain some experience with getting a PCB professionally manufactured by a board house. For several years I have done my own designs but I always milled and drilled them myself. This had pros and cons. I never had to worry about silk screens or solder masks because my boards never had any. On the other hand I suffered from the lack of plated-through holes. Vias were always a pain in the arse because I had to manually solder in pieces of wire to connect the two sides. And it was very difficult if not impossible to put a via below a component which made the layout challenging when working with ICs with many and/or tightly spaced pins.
More details at Soldernerd homepage.
